Rimonabant, Gastrointestinal Motility and Obesity
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چکیده
منابع مشابه
Rimonabant, Gastrointestinal Motility and Obesity
BACKGROUND Obesity and overweight affect more than half of the US population and are associated with a number of diseases. Rimonabant, a cannabinoid receptor 1 blocker in the endocannabinoid (EC) system, was indicated in Europe for the treatment of obesity and overweight patients with associated risk factors but withdrawn on Jan, 2009 because of side effects. Many studies have reported the effe...
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Drugs that interfere with cannabinoid CB1 receptor transmission suppress a number of food-related behaviours and these compounds are currently being assessed for their potential utility as appetite suppressants. Rimonabant (SR 141716A) is a cannabinoid receptor 1 (CB1) antagonist-inverse agonist which was developed for obesity treatment [1]. Clinical trials showed that rimonabant caused cumulat...
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BACKGROUND Changes of gastrointestinal motility, which are important related to the food digestion and absorption in the gastrointestinal tract, may be one of the factors in obesity-formation. AIMS The changes of gastrointestinal motility were explored in the rats from diet-induced obesity (DIO), diet-induced obese resistant (DR) or control (CON) by diet intervention. METHODS After fed with...
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Anatomic regions of the stomach are the fundus, corpus (body), antrum and pylorus. The functional regions of the stomach do not correspond to the anatomic regions. Functionally, the stomach can be divided into the gastric reservoir and the gastric pump (Fig. 1). The gastric reservoir consists of the fundus and corpus. The gastric pump is represented by the area at which peristaltic waves occur:...
متن کاملGastrointestinal Motility
Gastrointestinal (GI) motility is an essential function of digestive and absorptive processes of the gut, required for propelling intestinal contents, mixing them with digestive juices, and preparing unabsorbed particles for excretion. Pivotal to the discussion of mechanisms for producing defined patterns of motor responses are important and intimately related aspects of intestinal neurophysiol...
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ژورنال
عنوان ژورنال: Current Neuropharmacology
سال: 2012
ISSN: 1570-159X
DOI: 10.2174/157015912803217297